Sentence examples for factor in limiting the efficacy of from inspiring English sources

For several types of cancer, ABCB1 overexpression may be the predominant factor in limiting the efficacy of chemotherapeutic agents.

In some cancers LDHB can replace LDHA, hence limiting the efficacy of the LDHA inhibitors [109, 222].

TACE-induced hepatic arterial damage is a factor that limits the efficacy of this treatment.

Graft survival and integration are major factors that limit the efficacy of cell therapies for the treatment of disease and injury in the central nervous system.

Additional factors that may limit the efficacy of AAV vectors in CF lungs are the sputum and bacteria-induced inflammation.

Lack of adherence to treatment seems to be a major factor limiting the efficacy and effectiveness of antiobesity drugs.

However, the blood brain barrier limits the efficacy of cefoperazone/sulbactam in intracranial infection.

While important for normal mammalian physiology, pleiotropy limits the efficacy of cytokines and growth factors as therapeutics.

Emergence of resistance may ultimately limit the efficacy of treatments as survival factors other than those targeted by ABT-737 enable cancer cells to evade apoptosis.

Inadequate apoptosis can limit the efficacy of HER2-targeting drugs such as lapatinib [ 8, 9], and BikDD gene therapy enhanced lapatinib efficacy in HER2-positive and epidermal growth factor receptor (EGFR -positive brEGFR -positivedels in vitro and in vivo, though no complete tumor regressions were obreastd.

The other two measure efficacy in limiting the adverse effects of climate change.