In the dawn of experimental vascular engineering, new biomaterial schemes for clinical growth factor administration that take better account of biological principles of angiogenic growth factor function and the cell biological basis necessary to produce functional vasculature are evolving.
Butera, D. et al. Autoregulation of von Willebrand factor function by a disulfide bond switch.
He went on to work in Gerald Rubin's laboratory on the development of novel microarray technologies for the genome-wide study of transcription factor function in D. melanogaster.
The HOMER findPeaks-style factor function was then used to identify genome regions in which more sequencing reads were present than would be expected by chance.
Pan, P. Y. et al. Reversion of immune tolerance in advanced malignancy: modulation of myeloid-derived suppressor cell development by blockade of stem-cell factor function.
Lickwar, C.R., Mueller, F., Hanlon, S.W., McNally, J.G. & Lieb, J.D. Genome-wide protein-DNA binding dynamics suggest a molecular clutch for transcription factor function.
Thus, zinc plays an important role in transcription factor function, antioxidant defense and DNA repair.
Inhibition of FoxM1 transcription factor function is a potential strategy for overcoming breast cancer progression.
Impaired growth factor function is thought to drive many of the alterations observed in Alzheimer's disease (AD) patients.
Multi-protein assemblages known as enhanceosomes govern gene expression by local committee thus dictating regional transcription factor function.
