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In this study, we determined the function of KLF14 in the regulation of forkhead box protein 3 (FOXP3), a transcription factor critical for T regulatory (Treg) cell differentiation.
An example is the known complex of ataxin-1, RORα, a transcription factor critical for cerebellar development, and tip60, a co-activator of RORα [26], [27].
This HMT may, in fact, be an integrative factor critical for maintaining epigenetic states that link histone modifications with DNA methylation states previously shown to be mediated by components of the REST repressor complex [10], [69].
Crx is an Otx-like homeobox transcription factor critical for photoreceptor differentiation and for maintenance of the transcriptional regulatory networks essential for normal retinal development [30]and pineal function[31] [33].
This study shows that hampering CRABP2, a factor critical for RA transport onto nuclear RARα, in cells with a functionally intact RARα, also leads to epigenetic repression of RA-responsive genes downstream of RARα, with heritable biological outcomes.
Wnts secreted by both TECs and thymocytes were shown to regulate Foxn1 expression, which is the transcription factor critical for thymic epithelial development and responsible for the athymic nude phenotype when mutated in mice and humans [38].
Similar(35)
Efforts should focus more on using public funds to educate poor communities about the factors critical for academic success, such as parental involvement, regular reading habits, good nutrition and large-scale mentoring programs.
Moreover, controversy persists as to factors critical for implant and prosthetic success.
Furthermore, we identified factors critical for experimental practice in effective engineering knowledge integration and innovation.
The angiopoietins are a family of growth factors critical for development and maintenance of the vasculature.
The redundancy analysis (RDA) indicated two groups of factors critical for ant community composition.
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