TBP: TATA-binding protein factor binds directly to the promoter and nucleates the assembly of a transcriptionally competent preinitiation complex.
The single initiation site model predicts that once a transcription factor binds to its DNA binding site, it remains bound for a long period of time, probably until an intracellular signal induces detachment [34].
Interestingly, NAC019 regulatory region has an MYB binding site, and MYB2 transcription factor binds to the NAC019 regulatory region in a yeast one hybrid assay [ 43].
When the right growth factor binds to it, it is like a key going into an ignition.
We have determined that a Myb transcription factor binds to the CD4 promoter and is critical for full promoter function.
Epidermal growth factor binds, phosphorylates, and activates epidermal growth factor receptors on the cell surface.
When the proper growth factor binds to this receptor, it sets off a series of reactions that spur cell growth and retard cell death.
To understand transcriptional regulation, it is necessary to understand the factors that determine where a particular transcription factor binds in the genome.
CST/AAF, a DNA polα.primase accessory factor, binds POT1b and shortens the extended overhangs produced by Exo1, likely through fill-in synthesis.
The approach is different from the new cancer drug Erbitux, developed by ImClone Systems, which blocks the epidermal growth factor receptor, the docking port on cancer cells to which the growth factor binds.
The switch is a molecule known as the epidermal growth factor receptor, which sits on the surface of cancer cells and is turned on when the proper growth factor binds to it.
