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Although Adr1 is not the dominant factor at this gene in terms of expression, it does bind to this promoter [9] and has a minor affect on expression.
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A reconciling model posits that transcription initiates by virtue of infrequent yet stable and productive association of factors at target genes (ChIP).
Thus, our study suggests that the Tip60 complex is important for mESC pluripotency by acting as a global transcriptional co-factor at active genes and distal regulatory elements.
It is not possible to test these unknown factors at this point; but synthetic gene design offers the ability to incorporate and test new gene design features as they become known.
To determine if GBAF complexes regulate the naive pluripotency program through facilitating Sp5 and KLF4, we profiled the occupancy of these factors at genes regulated during the ESC-EpiESC transition.
These results suggest that genomic PKA proteins facilitate and/or prolong hyphal morphogenesis by acting on nearby transcription factors at genes regulating morphogenesis.
In Drosophila, it has been shown that the binding of promoter-proximal stalling factors at inactive Hox genes helps organize insulator loop domains [ 20].
Previous whole-genome chromatin immunoprecipitation analyses have identified a wide set of Oct4 target genes [6], [28], as well as describing co-occupancy of Oct4 and other transcription factors at many of these genes [6].
A '+' designates the presence of a motif in the PA sigma factor gene at the left.
A '+' designates the presence of a motif in the ECF sigma factor gene at the left.
Tan's genomic research has discovered certain factors at the gene level that make liver-fluke positive CCA different from other CCA.
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