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These are both important shortcomings, as changes in the amount of expression of a transcription factor affect its intracellular mobility [3], ability to interact with members of the transcriptional apparatus and to transcribe target genes [16], and cell cycle dependent sensitivity to AR functions have been suggested (see below; [17]).
We conducted an analysis examining the impact of how different distributions of a dichotomous prognostic factor affect the power (and sample size needed to obtain 80% power) to detect an interaction between the prognostic factor and treatment in RCTs.
Although NaOCl has many properties, activation techniques as an external factor affect the dynamic balance of NaOCl use, increasing its tissue dissolution ability, based on activation with sonic or ultrasonic devices, and heating the solution [ 4, 9, 10].
This is in contrast with the mechanism which is generally expected in clusters of trans-eQTLs, where a causative polymorphism may affect the downstream expression of a target gene and this gene, e.g. transcription factor, affect the expression of the other genes involved in the cluster.
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