Exact(9)
In fact, binding of bivalent ligands shows a considerable avidity effect; affinity of a dimeric myosin 5a fragment has been recently reported to be ∼40 nM [20].
This confirms that the compounds are in fact binding at the AF2 site.
In fact, binding of LPS to collagen type II can significantly be reduced by antibodies against collagen type II.
In fact, binding of either ATP or ADP to PKA critically depends on Mg2+ ions (23, 32, 34, 35, 47).
If Kaiso is in fact binding methylated DNA, it is likely doing so via the Kaiso methylated motif (because the unmethylated motif does not contain a CpG).
In fact, binding sites for other transcription factors have been found close to replication origins and have been implicated in origin activation in both yeast and mammals [ 39– 42].
Similar(51)
In fact, bindings of many TFs are tissue specific and condition dependent.
But even as details pour in about John Allen Muhammad and John Lee Malvo and about the sudden coalescence of facts binding them to the sniper attacks, the pall over life in the Washington area has begun to lift.
In fact, the binding of Aβ radiotracers to Aβ fibrils shows typical, reversible binding properties in in vitro kinetic binding analyses [ 18].
Finally, most golgins have been shown to bind to Rab GTPases and in fact Rab binding has been considered a hallmark feature of golgins [5].
Although the key to their catalytic cycle is the fact that binding and positioning of primary substrate precede O2 activation, the means by which substrate binding stimulates turnover is not well understood.
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