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This underscores a major challenge facing efforts to rationally design "biased" GPCR ligands for therapeutic application.
Ms. Burke and another administration official testified at a State Assembly hearing that underscored the steep challenges facing efforts to improve the system.
Major challenges facing efforts to prevent the spread of the disease to polio-free countries included the hajj and ʿumrah pilgrimages to Mecca, each of which involved large-scale population movements of people from the remaining polio-endemic countries in south-central Asia.
There are several challenges facing efforts to develop the use of mobile transactions.
We want to beat the competition, but we're really using the competition to trigger us to get to the patient". Despite the historic promise presented by the treatment, Jimenez says, the biggest hurdle facing efforts to develop new cancer cures might be economics, not science.
They've persisted against tear gas, pepper spray, rubber bullets, having military weapons pointed at them, being hit and kicked by police, and facing efforts by authorities to single out protest leaders for arrest.
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Along with Iran to the south, Azerbaijan is still locked in hostility with its western neighbor, Armenia, and faces efforts by Russia to reassert its political and economic prowess in the former Soviet republics.
As in the Madoff case, investors who received payouts from Vaughan in recent years may face efforts by the bankruptcy trustee to claw back the money.
If Zuma rebuffs that call, he could also face efforts to remove him through a parliamentary vote.
Amid the many problems facing relief efforts in Haiti are sharp increases in air cargo costs for emergency supplies that may endure longer than usual.
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