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We thank the staff of the Max Planck Institute for Molecular Genetics (MPIMG) and PICTIBiSA@BDD imaging facilities for technical assistance, the MPIMG sequencing core facility of sequencing services and the MPIMG IT facility for support in using the computing cluster.

The final 140 150 nt products were purified and sequenced in the Deep Sequencing facility of the IGBMC using the Illumina sequencing platform.

We thank W. Jin for his insights into the bioinformatics analysis of the data, the National Heart , Lung and Blood Institute (NHLBI) DNA Sequencing Core facility for sequencing the libraries and the NHLBI Flow Cytometry Core facility for sorting the cells.

We thank Dr. John Leszyk of Proteomic Mass Spectrometry Facility at UMMS for mass-spectrometry analysis to identify the WRN acetylation sites and the Nucleic Acid Facility of UMass Medical School for sequencing the plasmids.

Full sequences were obtained by Sanger sequencing via the sequencing facility of Radboud UMC.

Plasmid was purified using Gene Jet Plasmid Miniprep Kit (Fermentas, St. Leon-Rot, Germany) and clones sequenced (commercial sequencing facility of GATC Biotech, Konstanz, Germany).

Bands of interest were excised for protein sequencing (Iowa State University protein sequencing facility) of N-terminal amino acids.

Cycle sequencing and sequencing was performed at the ASGPB sequencing facility of University of Hawaii at Manoa (http://asgpb.mhpcc.hawaii.edu).edu

The amplicons were purified and sequenced at the sequencing facility of Chromous Biotech, Bangalore, India.

Sequencing was performed at the DNA sequencing facility of GenProbio s.r.l., Italy (http://www.genprobio.com/).

HiSeq Illumina sequencing was performed at the core sequencing facility of the King Abdulla University of Science and Technology (KAUST), Jeddah, Saudi Arabia.