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Are there simple mechanisms of mitigating clonal interference and thus accelerating adaptation?
These observations are consistent with the established ability of mutator alleles to accelerate adaptation in novel environmental conditions [7], [36].
Genetic recombination has been proposed to accelerate adaptation by combining beneficial mutations that arose in independent lineages.
The potential for accelerated adaptation to humans should be monitored through improved surveillance.
Martens and Hallatschek [ 36] showed that recombination accelerates adaptation in spatially structured populations through the Fisher-Muller effect, but their model did not incorporate a free DNA pool.
The accelerated adaptation to shifts in LD cycle suggested an alteration in the phase-resetting effect of light in the SCN of CK1ε−/− mice.
A recent study published in The Journal of the American Medical Association (JAMA) identified multiple reasons why the Apple Health Records available on iPhones may accelerate adaptation of Personal Health Records PHRR).
In contrast, sexual reproduction efficiently eliminates deleterious mutations [ 11] and creates genetic variation that favors natural selection and accelerates adaptation to changing environments [ 1].
This should be a first step in any decision regarding the genetic management of captive populations because it determines how genetic adaptation to captivity needs to be considered, especially if mate choice accelerates adaptation to captivity.
In conclusion, the GEMM-ESC method performs well on all fronts and can be routinely applied in transgenic facilities to accelerate the generation and adaptation of mouse models.
Socio-cultural norms shift over time, and long-term investments in facilities may accelerate this shift; meanwhile, cost and access do remain important barriers to the use of facilities for giving birth.
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