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However, the limited effect observed after the coexpression of ABCA1 and CD36 prompted us to consider that CD36 could act independently from the ABCA1 facilitator function whereas MEGF10 appeared highly sensitive to the presence of the transporter.
On the other hand, most amino acids have similar concentrations in the vacuolar lumen and in the cytoplasm [19], which is in accordance with a Gln facilitator function of CAT8 at the tonoplast.
The facilitator function of the exocyst provides increased rates of vesicle docking and fusion events, and it has been speculated that this may involve an exocyst role in localized SNARE assembly [ 20- 23].
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The emerging model thus identifies the basal body/transition zone as a hub controlling access to the cilium, where ciliopathy proteins localized at this entry-point facilitate the selective entry of ciliary-bound proteins through a role in vesicle trafficking (entry-facilitator function) (23, 42, 45) and restrict access to the cilium to non-ciliary-targeted proteins (gate-keeper function) (39, 41).
This gate-keeper function differs from the entry-facilitator function for Cc2d2a identified by our work, in that the former is required to keep non-ciliary-directed proteins out of the cilium, whereas the latter is actively required for the entry of ciliary proteins.
The facilitators function was to encourage participants to talk freely [ 26].
The facilitators functioned best if coming from the same geographical area as the groups and if they were able to come to terms with the chair of the groups.
No evidence of transfer of facilitative function was obtained between the tone and the remaining drug facilitator.
Based on the accumulating functions of Wt1 in different stages of kidney development as shown here, we extend this to propose a 'master facilitator' role for Wt1.
The effects produced by the combined administration of a GABAergic function facilitator and inhibitor (CDP/PTZ and CDP/Ro15-4513) were also investigated.
The MCD facilitator does not function as an ethics expert or consultant [ 5, 6, 10].
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