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Interestingly, nitric oxide (NO), generated by iNOS, reportedly augments the synergistic interaction between E1AF and its transcription coactivator CBP/p300, resulting in the facilitation of induction of tumour-related genes, such as COX-2 (Liu et al, 2004).
These studies have shown that HSPs act both as adjuvants by triggering TLRs on cells of the innate immune system, in particular macrophages and DCs, and also as carriers of antigens by providing a mechanism for chaperoning polypeptides for the loading of MHC molecules and the subsequent facilitation of induction of acquired immunity [ 32– 32].
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The decreased dependence on the intracellular Ca2+ appears to be the main cause of the facilitation of LTD induction in the mutant mice.
Surgical lesions of the VNO eliminate important olfactory-dependent neuroendocrine functions in female mice, including mate recognition and pregnancy block, facilitation of lordosis, puberty acceleration, and induction of estrus [ 2, 8- 11].
In summary, DC foster graft vs NB reactivity through three main mechanisms: facilitation of immune maturation, non-specific activation and induction of antigen-specific GvT reactions.
Some evidence was found for the facilitation of benzo[a]pyrene hydroxylase activity expressing the enzyme induction in the microsomal fraction of pyloric caeca of seastars, at increasing PCB concentrations.
See Faraday's law of induction.
Completion of induction.
The step of induction.
Furthermore, our current data confirm a significant role of DC in stimulation of lymphocytes and facilitation of tumour antigen recognition demonstrated by vaccine approaches to induction of anti-tumour immunity using tumour cells modified to express costimulatory molecules and cytokines (Bausero et al, 1996; Johnson et al, 2005) and allogenisation of tumour MHC (Kobayashi et al, 2007).
This study revealed that CRR cells were refractory to the induction of autophagy after irradiation and that facilitation of autophagy by rapamycin (RPM) abrogated the CRR phenotype.
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