The advantages of adaptive pacing in fMRI of impaired subjects are expected to be the acquisition of more informative data per unit time, less contamination of data by correlates of non-language processes such as emotion, and facilitation of experiments that combine normal and impaired subjects.
In addition, paired-pulse facilitation (PPF) experiments were performed to assess pre-synaptic plasticity [25], and no significant difference was observed between 3 4-month-old Tg2576 and WT mice (Figure S2B).
In paired pulse facilitation (PPF) experiments, significant differences were observed in fEPSP slope across genotypes among all interstimulus intervals.
In paired pulse facilitation (PPF) experiments, we observed significant differences in fEPSP slope across genotypes among all interstimulus intervals.
To determine the impact of misaligned feeding on presynaptic neurotransmitter release probability, paired pulse facilitation (PPF) experiments were performed at 25, 50, 100 and 250 msec intervals.
As was previously shown for drug-induced potentiation of mammalian VTA [8], the level of presynaptic facilitation in our experiments was similar after birds had performed directed or undirected singing (Fig. 4; p>0.20, t-test for each comparison).
If the facilitation demonstrated in Experiment 2 was driven by the remembered position of the waveform at motion offset, rather than by an interaction involving subsequent static input, performance should be unaffected by the transient removal of the static test waveform.
Rhythmically uttering "pataka" could have led to a tendency for comparable and unspecific intersensory facilitation in our experiment.
The delay hypothesis predicts that tones directly preceding the target will still facilitate recognition, but any account on which the facilitation in the previous experiments results from listeners interpreting the content of delays as a signal predicts no effect.
This finding correlates with enhanced synaptic facilitation in paired-pulse experiments and hippocampal LTP in living behaving mutant mice.
