Sentence examples for facilitating viral entry from inspiring English sources
In this context, TNF and IL-6 can lead to increased T cell replication, presumably by up-regulation of molecules such as CCR5 on the surface of lymphocytes, thus facilitating viral entry.
With the eight target sulfoforms of the N-terminal region of CCR5 in hand (compounds 2– 9), we were next interested in investigating the effect that discrete CCR5 sulfation patterns had on mediating binding with the HIV-1 Env glycoprotein gp120 and facilitating viral entry.
The viral protein HIVgp41 is an attractive and validated drug target that proceeds through a sequence of conformational changes crucial for membrane fusion, which facilitates viral entry.
This site however has evolved to facilitate viral entry.
ORF S/pre-S codes for viral surface glycoproteins (HBsAg) that bind to cell receptors and facilitate viral entry [ 7].
We used polybrene at 8 μg/mL final concentration to facilitate viral entry and then incubated the cells for 16 hours at 37°C in a humidified incubator in an atmosphere of 5% CO2.
Although the receptors for some viruses have not been clearly defined, the sites in the spike proteins of these viruses for binding to the cellular cofactors that facilitate viral entry may also be used to design vaccines able to induce antibodies to block viral entry or neutralize viral infectivity.
Reflecting the need for specific host cell molecules that facilitate viral entry into target cells, the tropism of HIV-1 is primarily governed by the expression of the entry receptor complex consisting of CD4 and CXCR4 or CCR5 on the surface of target cells.
In the present review, we discuss recent structural studies which have led to a better understanding of the various mechanisms by which different paramyxoviruses use their attachment glycoproteins to hijack specific protein and glycan cell-surface receptors to facilitate viral entry.
Here, we discuss how SARS-CoV S facilitates viral entry into target cells and illustrate current approaches that are used to inhibit this process.
This may lead to a low level induction of the receptor-induced signaling cascades, such as PI3K/Akt that facilitates viral entry.
