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Tiam1 belongs to the Dbl-family of guanine nucleotide-exchange factors (GEFs) that contain the Dbl-homology (DH) and Pleckstrin-homology (PH) tandem (DH PH) domain, which directly catalyses the GDP/GTP exchange reaction in the GTPase cycle and thus facilitating the switch between inactive GDP-bound and active GTP-bound states (Mertens et al, 2003).
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In a recent study, Paydafar [22] showed that a specific wave form of noise facilitates the switch between a stable fixed point and a stable periodic solution.
The fact that Pol31 and Pol32 may be associated with either PolDelta or PolZeta facilitates the switch between these two polymerases when the former encounters a lesion on the template.
This is of special interest because 6S RNA itself is a regulator, considered to facilitate the switch in specificity between exponential and stationary growth transcription by interfering with the Eσ70 holoenzyme [45], [46].
Bcl-xL has been found to complement S.cerevisiae genes that facilitate the switch from glycolytic to oxidative metabolism [12].
In contrast, we demonstrate here that loss of Arf significantly accelerates tumor formation, via facilitating the angiogenic switch.
These findings indicate the possibility that viral protein(s) might modulate the switch between autophagy and apoptosis to facilitate their own replication.
In conclusion, identification of DIAPH3 as a protein capable of mediating the switch between mesenchymal and amoeboid phenotypes provides new insight into the molecular processes of metastasis, and may facilitate design of more effective strategies against advanced disease.
The unexpected nucleophile tolerance suggests that chemically versatile intermediates such as TEVSer/CysX exist that could facilitate the phylogenetically observed switch between protease clans that differ in their nucleophiles prior to specialisation.
The switch between two consecutive activities includes the number of occurrence of a switch and the direction of this switch.
The supervisory control is adopted to facilitate the automatic switching.
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CEO of Professional Science Editing for Scientists @ prosciediting.com