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Moreover, the mutation of L151S enhanced the activity in the range of 37 70 °C and pH 2.5 7.0 by facilitating the interaction between the substrate and the catalytic centre.
We show that WRAP53β targets the E3 ligase RNF8 to DNA lesions by facilitating the interaction between RNF8 and its upstream partner, MDC1, in response to DNA damage.
The gerPABCDEF operon has been suggested to play a role in facilitating the interaction between germinants and their receptors in spores of Bacillus subtilis and Bacillus cereus.
This gene was selected because Itch, an E3 ubiquitin ligase, amplifies TGFβ signaling by facilitating the interaction between the TGFβ receptor and SMAD2 [ 47].
The translocated MYBBP1A promoted p53 acetylation and accumulation by facilitating the interaction between p53 and histone acetyltransferase p300; thus, MYBBP1A could enhance p53 target gene transcription [ 13].
ATP-binding induces conformational changes in the N-terminus that allows MutL monomers to dimerise (Ban et al, 1999), thus facilitating the interaction between hMLH1 and hPMS2.
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Within the CCNE-T, this nanoinformatics core has a special role in facilitating the interactions between different NCI Alliance members, especially from a data exchange perspective.
These proteins may act as "adapters", facilitating the interactions between different pathways which may themselves evolve as units without coevolution between pathways.
It is reported that the dynamic alterations of chromatin looping can either activate or suppress gene expression by facilitating the interactions between enhancers or silencers and their target genes.
Furthermore, the nuclear lncRNA FOXM1-AS was found to facilitate the interaction between ALKBH5 and FOXM1 nascent transcripts to promote the HUR binding.
Mechanistically, USP15 S678A mutant failed to deubiquitinate BARD1 in response to MMC treatment, and in turn failed to facilitate the interaction between BARD1 and HP1γ (Supplementary Fig. 5f, g).
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