Based on these data, we suggest that SEB facilitate sensitization of the intestinal mucosa to OVA.
49– 51 It has also been suggested that sensitization to one allergen facilitates sensitization to another unrelated chemical.
Other events, including intestinal infections or influenza, may trigger or facilitate sensitization and thus development of a food allergy.
Intrinsic factors (eg, genetic factors such as mutations in the filaggrin gene) and exogenous factors (eg, alcohol, anti-inflammatory drugs, pathogens, or stress) have been proposed to reduce the barrier function of the intestinal epithelium and facilitate sensitization.
As the pathogenesis of migraine is linked to the trigeminal innervations of the cranial blood vessels, noxious stimuli from the cervical structures may also play a role in this pathogenesis by facilitating central sensitization [21].
The biological components may also have synergetic effects with other components of the PM, such as diesel exhaust enhancing IgE production and thus facilitating allergic sensitization [ 26].
The correlation between pericranial tenderness and short sleep duration, confirmed what we previously observed in adults, that the loss of sleep could facilitate central sensitization [8].
Reduced habituation to pain, common to migraine and FM [10], may facilitate central sensitization and myofascial pain persistence in the presence of other favouring conditions such as anxiety and sleep disturbances.
However, anxiety, more than depression, would be predictive of the long-term migraine persistence and the headache-related disability [42 44], for a probable linkage to the phenomena which might facilitate central sensitization.
While this state of putative disinhibition/facilitation did not appear to impact the perception of thermal stimuli during the interictal phase, we hypothesize that it may facilitate central sensitization at the onset of migraine.
