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NA is an antiviral target of high pharmaceutical interest because of its essential role in cleaving sialic acid residues from cell surface glycoprotein and facilitating release of virions from infected cells.
The molecular mechanisms facilitating release of eDNA have been studied in P. aeruginosa [17], S. aureus [7], and Enterococcus faecalis [12].
Though many technologies facilitating release of encapsulated cargo from polymeric carriers using NIR radiation have been developed, all of them originate from only a handful of photochemical and photophysical strategies, which present drawbacks that limit the extent of their application.
These properties have led us to hypothesize that nanocarriers containing PHis blocks result in enhanced gene delivery by inducing endosomal swelling via the proton sponge effect and simultaneously interacting with and disrupting the lipid bilayer membrane of the endosome and facilitating release of the cargo.
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The nanoporous ultrathin architecture is binder-free and beneficial for improving electrochemical active surface area, enhancing mass transport and facilitating releasing of oxygen produced during water electrolysis.
Metal molds precoated with a substance that facilitates release of the crème also are used.
Finally, the bacterial carrier was fabricated by permeabilizing the constructed strain to facilitate release of the lycopene cargo.
In this study amino acid residues around the RPLKPW sequence were optimized with a use of synthetic peptides to facilitate release of RPLKPW by gastrointestinal proteases.
MTT cytotoxicity assay and confocal microscopy images were carried out to determine whether Pluronic P85 could facilitate release of Dox from Doxil®.
Very low drug release was observed with the paddle method owing to poor dispersibility of the lipids in the dissolution media, whereas the Bio-Dis method hydrodynamics facilitated release of the drug by emulsifying the formulation in the medium.
Suspensions of the model microalga Chlorella sp. TISTR 8990 were pretreated by ohmic heating to facilitate release of lipids from the cells in subsequent extraction and lipase-mediated transesterification to biodiesel.
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CEO of Professional Science Editing for Scientists @ prosciediting.com