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This study highlights the potential of using a biomimetic scaffold to design a site-specific niche-like unit for facilitating proliferation or differentiation functions of BM-HSCs.
For example, miR-21, which is activated in part via aberrant EGFR signaling represses expression of PTEN and PDCD4, facilitating proliferation, invasion, and resistance to apoptosis of lung cancer cells [7] [11].
The immune response induced by cytokines provides the tumor cells with factors facilitating proliferation and attack on surrounding tissues.
Altogether, this indicates that canonical Wnt signalling is activated, likely diminishing thereby cardiogenic differentiation and facilitating proliferation.
Furthermore, they also illustrated that the overexpression of β-catenin may be an important contributing factor to glioma progression by means of facilitating proliferation and inhibiting apoptosis [ 51].
The remodeling of Ca2+ signaling is a common finding in cancer pathophysiology serving the purpose of facilitating proliferation, migration, or survival of cancer cells subjected to stressful conditions.
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The results indicate that the cell-adhesive PDM scaffolds facilitated proliferation and viability, while differentiation was augmented when the cells were encapsulated in the non-adhesive XLHA gels.
Interleukin-6 facilitates proliferation of Kras-mutated NSCLC.
SAPP α, in turn, may facilitate proliferation by activating the PI3K/Akt/mTOR pathway.
This suggests that preventing nuclear localization of Bcl-3 in colon cancer cells facilitates proliferation of these cells.
At lower concentrations (10 20 μM), LacCer stimulated DNA synthesis to facilitate proliferation by producing small quantities of superoxide.
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CEO of Professional Science Editing for Scientists @ prosciediting.com