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As a result, adapted parasites could be propagated to maximum cell densities of >2 × 106 cells/ml, facilitating in vitro antigen production in preparative quantities comparable to the conventional method.
Recently, it was reported that Timeless, a protein that protects the replication fork, associates with TRF1 and TRF2, thereby facilitating in vitro telomere replication in Xenopus egg extracts.
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Finally, Jonathan Himmelfarb's group will review how the use of three-dimensional kidney microphysiological systems can accelerate drug development by facilitating in vitro-to- in vivo scaling of a drug candidate from the preclinical phase to clinical trials, and how these systems can enhance patient safety by predicting human toxicity.
HyA90 and HyA600 facilitated in vitro osteoclast formation.
Our previous studies showed that decellularized cell-deposited extracellular matrix (ECM) provided an in vivo-mimicking microenvironment for MSCs and facilitated in vitro cell expansion.
This is the first report of the preparation method of β-SQDG-C18 vesicles, which should facilitate in vitro and in vivo application.
Simulated gastrointestinal media have been developed covering fasted and fed states to facilitate in vitro prediction of gut solubility and product dissolution.
Identification of these ubiquitylation regulators would facilitate in vitro reconstitution of ERAD ubiquitylation.
The instability of 2UIM ataxin-3 and its propensity to aggregate suggest that while 2UIM ataxin-3 is less physiologically relevant than 3UIM ataxin-3, the 2UIM isoform may better facilitate in vitro studies of ataxin-3 fibrillization and aggregation or high throughput screening assays based on aggregation.
47, 151 Optimization of this approach facilitated in vitro reconstitution of complex signal transduction pathways.
Cell lines are useful tools to facilitate in vitro studies of many biological and molecular processes.
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