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The conserved Asp134-Lys114-Glu232 ionetworknetogetherogether with the Mg2+ ion, likely play a role in facilitating departure of the leaving phosphate group.
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Unmiss recently told its humanitarian partners it would begin facilitating departures for residents from one of the smaller POC sites in Bor, according to an aid worker who sat in on that meeting.
Mg2+ ion B is bound between the γ- and β-phosphates and acts as a Lewis acid to stabilize the pentacovalent transition state and facilitate departure of the oxyanion.
The syn-dehydration reaction catalyzed by t3HypD requires a general basic catalyst to abstract the proton from the α-carbon; its conjugate acid likely functions as the general acidic catalyst to facilitate departure of the 3-hydroxyl group.
U.S. forces may have left the scene — the troop surge facilitating their departure — but the conflict continues, its outcome yet undetermined.
Facilitating his departure not only left everyone feeling positive but also set up an ambassador for our culture at another company and added to a strong pool of alumni advocating for us in the marketplace.
The women present in court were guilty of facilitating the departure of Islamic State recruits and collecting money for organizations aiming to radicalize young girls.
The general base that abstracts the 2-proton is the Tyr 159-Arg 147 dyad in the "150 180s" loop between the second and third β-strands; the general acid that facilitates departure of the 3-hydroxyl group is His 212 located at the end of the third β-strand.
Dehydration would then occur by His 191 functioning as the general acid that facilitates departure of the hydroxide leaving group, yielding compound 2. Compound 2 then undergoes a 1,2-hydride transfer similar to the benzylic acid rearrangement to produce 3-deoxy d- xylo-hexarate or 3-deoxy d- lyxo-hexarate.
In certain wild-type and H334R HDAC8-inhibitor complexes, these residues are disordered between "in" and "out" conformations; the "out" conformation of Trp141 is required to facilitate acetate departure through product release channels during catalysis.
His 191, which forms an H-bond with the departing hydroxide at C3, facilitates the departure of the hydroxide leaving group.
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