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MZ B cells are maintained in the periphery of the B cell follicles in the spleen, and it is possible that PI3Kδ promotes their survival by facilitating adhesion to the matrix in the marginal zone (Durand et al. 2009).
Once activated, platelets as well as factors released from them promote metastasis by increasing survival of cancer cells within the circulation and facilitating adhesion to the endothelium, extravasation, and ultimately the growth of tumor cells at metastatic sites [ 8, 9, 12- 17, 23, 24].
In addition to directly facilitating adhesion to the extracellular matrix [ 22, 23], CD26 has two associated enzymatic activities: an intrinsic dipeptidyl peptidase IV (DPPIV; EC 3.4.14.5) activity and a hydrolase activity due to anchored ecto-adenosine deaminase (ADA; EC 3.5.4.4) for which CD26 is the major binding protein [ 15].
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A previous study suggested that the surface bound plasminogen may contribute to the colonization of the oral cavity, since it facilitates adhesion to pharyngeal cells [37].
The ToxB protease was demonstrated to post-transcriptionally stimulate expression of LEE4 proteins and facilitate adhesion to epithelial cells [26], [27].
The release of these integrin subunits may explain why the peptide is also anti-adhesive for endothelial cells, given that the latter utilize αv- and β5-containing integrins to facilitate adhesion to the substratum [33].
However, CC23K1 differed from CC82K1 by the presence (100% vs. 0%, respectively) of genes mrkD coding for the type 3 fimbriae adhesin, which facilitates adhesion to the basement membranes of several human tissues [53], [54], and allS, coding for the activator of the allantoin regulon [30].
These factors may facilitate adhesion to and invasion of (specific) host cells.
Many bacterial pathogens contain surface proteins that facilitate adhesion to and/or invasion of the host mucosal barriers [ 66, 67].
As for Opa proteins, in unencapsulated meningococci, Opc is able to facilitate adhesion to and invasion of epithelial and endothelial cells independently of other adhesins [ 111].
The interviewed physicians reported that receiving prime vaccines during the first 12 months would facilitate adhesion to vaccination schedule (Quote 16).
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