An understanding of how peptides bind to MHC molecules is important for determining the structural basis for T cell dependent immune responses and facilitates the structure-based design of peptides as candidate vaccines to elicit a specific immune response.
The 3D registered data from the speech corpus is parameterised in a manner which facilitates the structuring of a state-based model.
In addition, study of the PBD-phosphopeptide complex also facilitates the structure-based optimization of lead compounds to identify a PBD-dependent inhibitor of PLK-1 [ 62].
The HPLC-SPE-NMR hyphenated technique facilitated the structure elucidation of three known and two new natural AFMR.
Finally, Fv-clasp antibodies showed superior "chaperoning" activity over conventional Fab fragments, and facilitated the structure determination of an ectodomain fragment of integrin α6β1.
To facilitate the structure determination process, we solved the NMR structures of both domains independently and utilized gas-phase cleavable chemical crosslinking and LC/MSn analysis to correctly position the domains within the full tetrameric AbrB protein structure.
Antibody Fab fragments have been exploited with significant success to facilitate the structure determination of challenging macromolecules as crystallization chaperones and as molecular fiducial marks for single particle cryo-electron microscopy approaches.
With the developed method, baseline separation was achieved for N-glycan isomers with α2-3/2-6 SA linkages, which facilitated the structure identification and quantitation of each isomer via LC-SRM analysis.
Subsequently, the progress in structural prediction of fusion proteins is presented, which can potentially facilitate the structure-based systematic design of fusion proteins toward identifying the best combinations of fusion partners.
Many structures of these components became available recently, including that of C1-inh, facilitating the structure-guided design of drugs targeting complement activation.
