Sentence examples similar to facilitates off target from inspiring English sources
It is therefore important to understand the genomic context that facilitates off-target activity of the deaminases in the absence of explicit DNA damage.
Reviewer 2 raised questions about how we handled the discussion of evolutionary implications of this study, noting that we do not show examples of how these "off target" biochemical interactions may facilitate the generation of novel cis-regulatory elements.
This made off target effects unlikely.
Such analysis can be used to facilitate hit selection, off-target evaluation and to better understand the biological mechanisms of interactions between small molecules and their targets, thus, to aid the discovery and development of chemical probes and novel drugs.
JAK is an upstream activator of both STAT3 and PI3K [ 23], thus when NSC 74859 inhibits STAT3, JAK could potentially facilitate the propagation off-target effects due to retroactive signaling from STAT3 to PI3K.
The availability of next generation high throughput sequencing will facilitate screening for off-target genomic effects including undesirable chromosomal effects resulting in translocations, rearrangements or deletions, which necessitate careful characterization and monitoring.
Availability of the complete R. microplus genome sequence data will facilitate screening for potential off-target effects.
In our approach, the use of computational chemoinformatics enabled the generation of hit compound network similarity graphs that grouped compounds based on chemotypes, facilitated compound target and off-target prediction, and identified analogs of validated inhibitors with the potential to be more potent, more specific, or less toxic.
