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Apart from schizophrenia and neurodegeneration, another key disease that would benefit from polypharmacological strategies is cancer, where several aberrant proteins and pathways concur to initiate tumor growth and to facilitate its progression.
A major task for a subset of these proteins is to first ensure that nucleosomes are partially or completely dismantled in front of transcribing Pol II to facilitate its progression across transcribed units and then to subsequently reassemble nucleosomes after Pol II passage.
It is well known that the accumulation of genetic alterations facilitates the progression of tumours.
Thus, p21 expression facilitates the progression of the disease.
Gravin-scaffolding of Aurora A and Plk1 facilitates metaphase progression.
This reduction is associated with androgen independence which facilitates disease progression [ 51].
Proinflammatory cytokines may be one of the mechanisms underlying the notion that chronic inflammation facilitates tumor progression [ 15].
One explanation for the link between resistance and malignancy might be that resistance facilitates cancer progression and invasion.
We challenge educators to strengthen meaningful learning that focuses on the patient perspective and facilitates the progression of nursing knowledge.
Bacterial endotoxin directly and indirectly facilitates cancer progression in vitro and in vivo through a multitude of complimentary mechanisms.
Cancer tissue contraction facilitates tumor progression and contributes to increased interstitial fluid pressure, which hampers drug delivery [ 5].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com