Here, opening of the cytosolic side of the 7-TM domain facilitates interactions with downstream effectors such as G-proteins (Rasmussen et al. 2011).
Toxic offline communities and systems abound; technology, as it has always done, facilitates interactions at each extreme of the human spectrum.
Inflammation-induced P-selectin (CD62P) expression on platelets and endothelial cells facilitates interactions among platelets and polymorphonuclear leukocytes (PMN), and can also promote coagulation.
Adjacent to the MADS-box is a 29-amino acid extension, referred to as the MEF2-specific (MEF2s) domain, which contributes to high-affinity DNA binding and dimerization with other homologous MEF2 proteins and facilitates interactions with other cofactors [9], [10].
LTX-302 consists of an idealized amphiphatic α-helical structure, which facilitates interactions with anionic surfaces.
RPS25 facilitates interactions of the ribosome with viral IRES elements (Landry et al., 2009).
In addition, alpha-actinin-4 connects the actin cytoskeleton to the membrane and facilitates interactions of the cortical cytoskeleton with cytoplasmic signalling proteins [ 130].
The reason for the proportionally larger effect in HFIP is not clear but may reflect the acquisition of structure in HFIP that facilitates interactions of IAPP with insulin.
