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Several mechanisms are considered to underlie this facilitated state, including dorsal horn reorganization, a loss of inhibitory control, a corresponding increase in dorsal horn excitability [33], [34] and associated with an increase in spinal glutamate release [35].
Failure to see an effect upon baseline responses in hippocampal systems parallels our observation that IT BoNT-B had no effect upon phase 1 formalin or acute nociception, but diminished the facilitated state.
The formalin model, the biphasic flinching behavior is believed to reflect the acute afferent excitation during the phase 1 and an ongoing low level of afferent traffic during the phase 2 of the behavioral response which evokes prominent flinching as a result of potent facilitated state initiated by the high level of afferent input observed during phase 1 [32], [32].
As pointed out in the response to Comment 3 above, we agree with the reviewers that implicit in our data is the possibility that "synapses are merely toggled between a basal state and a facilitated state".
We have added an explicit discussion of the notion that the overall strength of synaptic connections is regulated by a homeostatic mechanism that toggles between a facilitated state and a nonfacilitated state, as determined by experience.
5) The authors should discuss the possibility that synapses are merely toggled between a basal state and a facilitated state (with 2 amplitudes of connections), such that the apparent restoration of a covert memory is actually just a switching back to the facilitated, which occurs more readily after priming.
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In 2011 Rwanda continued rapid realization of Millennium Development Goals in facilitating state building, alleviating poverty, diminishing corruption, and improving health and education.
*Ensure that all children learn to read by reforming Head Start and by facilitating state reading initiatives that focus on scientifically based reading research... Higher Education... We renew our call for replacing "family planning" programs for teens with increased funding for abstinence education, which teaches abstinence until marriage as the responsible and expected standard of behavior.
Fifth, in arranging non-state initiatives, third parties might play important roles in facilitating state engagement.
When an auxiliary cavity mode is exploited, two approaches are proposed to effectively eliminate the optomechanical bright mode, and only the optomechanical dark mode is left to facilitate state transfer.
I interpreted "executive actions" to mean promulgating regulations and rules, facilitating state- and community-level programs, and funneling more dollars to renewable energy R&D.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com