Sentence examples for facilitated opening of from inspiring English sources

The isoflavonoid genistein facilitated opening of HCN1 and HCN2 channels, and this facilitation of channel opening persisted in HCN1 channels lacking only their CNBD, but not in channels missing the entire carboxy-terminal domain including the C-linker [32].

We observed that introduction of asymmetry in the valve geometry created points of weak adhesion between the valve and the substrate, which facilitated opening of the valve at lower actuation pressures.

Similar to the flavonoids, 5-chloroindole facilitated opening of EAG1 channels at more hyperpolarizing potentials (Fig. 6). 100 µM 5-chloroindole shifted the Vhalf of the conductance versus voltage relationship by an average of −8±5 mV, N = 3 (Fig. 6B).

These contacts may facilitate opening of the NCP structure required for INO80 mediated H2A/H2B exchange.

This intimate association suggests that the TMD helix may facilitate opening of the lateral gate.

Intergenic bends are often associated with regulatory elements and could facilitate opening of the DNA double helix at the transcription initiation sites.

The ATP-independent regulators PA28 and P200 can also facilitate opening of the 20S proteasome entry gate and contribute to substrate degradation (Stadtmueller and Hill, 2011).

Import may be initiated through a PTS1-binding induced conformational shift in the TPR domain [45] which facilitates opening of the PEX5 PEX14 transient pore [15].

These so-called 'pioneer' factors are believed to facilitate opening of chromatin at enhancers to enable lineage specific transcriptional regulation [ 70- 72].

Structural comparison of the inward facing PepTSt structure with the occluded conformation of PepTSo supports our previous model where we proposed the C-terminal domain is more dynamic, with helices H10 and H11 facilitating opening of the central peptide-binding site to the interior of the cell during transport.

Mechanistically, the interaction between the Med18-Med20 sub-complex and the Rpb4/Rpb7 sub-complex of Pol II has been proposed to alter the conformation of the Pol II clamp domain to facilitate opening of its active-site cleft and thereby the access of promoter DNA to the Pol II cleft [ 44].