Sentence examples for facilitated by structural from inspiring English sources

Optimization of inhibitory potency can be facilitated by structural information about inhibitor target binding.

These hits are then optimized to more potent compounds via medicinal chemistry, usually facilitated by structural biology.

In comparison to other athletic species of similar size, the aerobic capacity or maximal oxygen uptake (VO2max) of Thoroughbreds is superior (>200 ml O2/kg/min) [3], [3], and is achieved by a remarkable oxygen carrying capacity and delivery facilitated by structural and functional adaptations involving the respiratory and cardiovascular systems [5].

This would be greatly facilitated by structural information.

Thus, it is inferred that the nonmutagenic replication bypass of γ-OH-PdG by pol η, pol κ, or pol IV is facilitated by a structural rearrangement of the adduct into its ring-opened structure.

In case of biological macromolecules, e.g., proteins, this process can be considerably facilitated by using structural templates for standard residues.

GSG1L favors the AMPAR desensitized state, where channel closure is facilitated by profound structural rearrangements in the AMPAR extracellular domain, with ligand-binding domain dimers losing their local 2-fold rotational symmetry.

The investigation of APH inhibitors that target the ATP-binding pocket was facilitated by the structural similarities between the aminoglycoside resistance enzyme APH(3' -IIIa and serine/threonine and tyrosine eukaryotic protein kinases (ePKs), especially in the N-terminal lobe [8] (Figure 1A,C).

These studies will be undoubtedly facilitated by continued structural and molecular modeling studies of these transporters.

This process is facilitated by the structural framework of Nuclear Matrix, a nucleo-proteinaceous meshwork.

Taken together, our results are consistent with the initial capture of metal by D70 and E96 and repositioning of Mg2+ facilitated by the structural plasticity of E96 in the active site.