Sentence examples for facilitated by mutations from inspiring English sources

The malignant progression of such abnormal cells could be further facilitated by mutations induced by earlier treatment.

However, malignant progression of early lung lesions in the V600EBRAF model can be facilitated by mutations in key genes including depletion of tumour suppressor TRP53 (Dankort et al, 2007) or constitutive activation of β-catenin (Juan et al, 2014), indicating that these early lesions are indeed precursors for adenocarcinomas.

Whitehead et al. propose that selection for such traits could be facilitated by phenotypic mutations (errors of transcription and, especially, translation).

This was facilitated by a mutation that lead to an upregulation of the glyoxylate shunt [ 23].

Hence, enzyme recruitment can be facilitated by any mutation that amplifies the cellular concentration of a catalyst to an extent such that a latent function rises to a physiologically relevant level.

Only phages that are endowed with disposable side tail fibers and facilitated by high mutation rate can quickly adapt to both the planktonic liquid culture and the benthic biofilm habitats.

Oncogene-independent maintenance of c- myc-induced mammary adenocarcinomas is facilitated by ras mutation, the oncogene-independent maintenance of activated Neu-induced adenocarcinomas and metastases is altered when they are transplanted to a different environment, and p53 heterozygosity promotes oncogene-independent maintenance and recurrence of Wnt1-induced adenocarcinomas.

Although EWS-FLI-1 has been shown to have the capacity to transform primary MPCs that express functional p53 and p19ARF [8], EWS-FLI-1 expression and transforming potential in primary unsorted bone marrow cells were found to be facilitated by inactivating TP53 mutations [23].

The prolonged maintenance of tightly linked compensatory and deleterious mutations facilitated by self-fertilization may be responsible for the fitness increase as linkage disequilibrium between the compensatory and deleterious mutations preserves their epistatic interaction.

Adaptive protein evolution may be facilitated by neutral amino acid mutations that confer no benefit when they first arise but which potentiate subsequent function-altering mutations via direct or indirect structural mechanisms.

The process of tracing Y chromosome and mtDNA lineages is facilitated by the existence of mutations, which serve as genetic markers and are carried by all the descendants of the individuals in whom the mutations first appeared.