Sentence examples for facilitated breakdown from inspiring English sources

Facilitated breakdown of ATP in the RVLM not only prevented an increase in plasma level of noradrenaline, but also attenuated the progression of LV remodelling in a rat model of heart failure secondary to MI.

Facilitated breakdown of extracellular ATP in the rostral ventrolateral medulla oblongata by virally-driven overexpression of a potent ectonucleotidase transmembrane prostatic acid phosphatase results in a significant reduction in the arterial blood pressure in the spontaneously hypertensive rats (but not in normotensive animals).

Furthermore, it was shown that facilitated breakdown of extracellular ATP-modulated sympathetic activity [ 65] and attenuated the development of hypertension in SHR [ 64].

These results show that activated RVLM astrocytes are capable of increasing sympathetic activity via release of ATP while facilitated breakdown of ATP in the RVLM attenuates the progression of LV remodelling and heart failure secondary to myocardial infarction.

In order to evaluate the role of this mechanism in sympathoexcitation associated with progression of heart failure, we developed a molecular strategy for facilitated breakdown of ATP in the RVLM based on a virally driven expression and insertion into the cellular membranes of a potent ATP-degrading enzyme TMPAP.

Thus, TMPAP expression and facilitated breakdown of ATP in the RVLM lowers arterial blood pressure in the SHR without affecting this hemodynamic variable in control animals, suggesting that ATP-mediated signaling contribute to the maintenance of systemic arterial hypertension in this model.

Heparanase can facilitate breakdown of the extracellular matrix which aids tumor cell migration and releases factors that promote tumor growth, angiogenesis and metastasis [1].

The functional repertoire of the intestinal cell differs: the apical side is equipped with the brush border containing a large number of enzyme and transporter complexes such as lactase, sucrase and aminopeptidase that facilitate breakdown and absorption of nutrients from the gut lumen into the blood circulation [25].

MMP7 and MMP12 levels are elevated in lung cancer, which may facilitate breakdown of the extracellular matrix and tumor spread.

Autophagolysosomes and phagolysosomes are terms used to describe the compartments within these two pathways that have undergone lysosome fusion which facilitates breakdown of internal components.

However, complex tumour-stromal interactions may result in changes to the stroma that facilitate breakdown of the basement membrane and allows tumour cells to invade the surrounding ECM.