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Additionally, end-tagging facilitated binding to bacterial lipopolysaccharide, both effects probably contributing to the selectivity displayed by these peptides between bacteria and eukaryotic cells.
Previous studies indicated that adenoviral capsids modified to contain a C-terminal poly-lysine tract allowed for an efficient transduction of multiple cell types via facilitated binding to cell surface heparan sulfate proteoglycans [ 20].
Adenoviral capsids modified to contain a C-terminal poly-lysine tract allow for efficient transduction of multiple cell types via facilitated binding to cell-surface heparan sulfate proteoglycans [ 20].
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MDP bind to NALP3 thereby facilitating binding to ASC (apoptosis associated speck-like protein containing a CARD) by a pyrin domain (PYD -PYD interaction.
The Ser216 phosphorylation of CDC25C on the other hand, attracts members of the 14-3-3 14-3-3 14-3-3 familytates binding to other proteins such as Chk1, Chk2 and c-TAK1, that can bind to and relocate CDC25C to the cytoplasm [ 27].
In sea anemone, small and basic α-pore forming actionporin proteins have a phosphocholine binding site which facilitates binding to the cell membrane and formation of pores, a feature that they share with toxins such as diphtheria and anthrax111.
Further analysis indicated that amino acid isoleucine (99), aspartate (102) and lysine (104) are anchor residues facilitating binding to HLA-DR3 molecules.
The estradiol portion of the molecule was designed to facilitate binding to steroid receptors in malignant cells, which is then followed by the intracellular release of the nitrogen mustard alkylating moiety.
In addition, chimeric fusion proteins have been engineered that incorporate in a single polypeptide chain heterologous protein domains which facilitate binding to plasmid DNA, specific recognition of target cells, induction of receptor-mediated endocytosis, and DNA transport through intracellular compartments.
Thus the BEK receptor, like FLG, also requires an interaction with heparan sulfate proteoglycans to facilitate binding to its ligands.
This reflects the fact that different HS structures are required to facilitate binding to VEGF165.
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