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To facilitate the structure determination process, we solved the NMR structures of both domains independently and utilized gas-phase cleavable chemical crosslinking and LC/MSn analysis to correctly position the domains within the full tetrameric AbrB protein structure.
Antibody Fab fragments have been exploited with significant success to facilitate the structure determination of challenging macromolecules as crystallization chaperones and as molecular fiducial marks for single particle cryo-electron microscopy approaches.
Our NMR results revealed that the two designed mutant molecules retain the specific interaction manner that exists between the wild type molecules and can facilitate the structure determination by NMR, due to the stable complex formation via an intermolecular disulfide bond.
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Subsequently, the progress in structural prediction of fusion proteins is presented, which can potentially facilitate the structure-based systematic design of fusion proteins toward identifying the best combinations of fusion partners.
The identification of the binding interactions in the EGFR/ligands and the ABL/ligands complexes can facilitate the structure-based design of new tyrosine kinase inhibitors.
From this, we propose a classification of PPI stabilizers based on their binding mode and the architecture of the complex to facilitate the structure-based design of stabilizers.
In Benin and Burkina Faso, all public initiatives to facilitate the structuring of the sector by defining an incentive-based regulatory framework appear to be frozen.
Thematic networks were constructed to facilitate the structuring, description, and interpretation of the themes [ 24].
A tissue array database (TAD) was, therefore, developed to facilitate the structuring, storage, and distribution of biomarker information.
The primary goal of the guidelines is to facilitate the structuring of an ethically responsible global health training program and to discourage the implementation and perpetuation of imbalanced and inequitable global health training experiences and programs.
The HPLC-SPE-NMR hyphenated technique facilitated the structure elucidation of three known and two new natural AFMR.
More suggestions(17)
facilitate the build
facilitate the organization
facilitate the configuration
facilitate the articulation
promote the structure
helping the structure
provided the structure
facilitated the structure
facilitate the set up
facilitating the structure
facilitate the systems
are the structure
facilitates the structure
improving the structure
facilitate the structuring
facilitate the structured
facilitate the mechanisms
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