The 5′ sequence (especially bases 2 7, termed the "seed sequence") of a miRNA, guides its complementary binding to the 3′UTRs of its target mRNAs and facilitates the repression of the latter in the RNA-induced silencing complex (RISC) [ 12– 15].
Bmi1 facilitates the repression of Hox genes to prevent inappropriate differentiation and induces downregulation of Dickopf (DKK) proteins, resulting in upregulation of the Wnt target c-Myc, which in turn leads to transcriptional autoactivation of Bmi1.
IHF is a key architectural protein involved in a variety of cellular processes and binds to consensus sequences in the csgD promoter to facilitate the activation or repression of csgD transcription.
Indigenous manpower in many imperial states was also subjected to slave conditions, dragooned into the imperial armies, or forcibly recruited into road gangs – building the primitive communication networks that facilitated the speedy repression of rebellion.
A greater understanding of the mechanisms of TNF-α-induced SOD1 repression could facilitate the design and development of novel therapeutic drugs for inflammatory conditions.
Finally, our results suggest that epigenetic therapies may facilitate the prevention or reversal of transcriptional repression responsible for chemoresistance and the restoration of sensitivity to platinum-based chemotherapeutics.
These findings indicate that the PcG/TrxG targets are regulated by multiple positive and negative regulators that facilitate the establishment and removal of PcG repression.
Taken together, our results suggest that in addition to its well-documented functions in transcriptional repression, Hdac1 may also facilitate the direct transcriptional activation of target genes during vertebrate embryogenesis.
Indirectly, it can facilitate the binding to methylated DNA of methyl-CpG-binding domain proteins, which can mediate gene repression through interaction with histone-modifying enzymes [ 28].
