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This adds to accumulating evidence that structural encoding of aversive experiences, through enhanced availability of post-synaptic dendritic surface and synaptic inputs on principal neurons of the BLA, may facilitate symptoms of chronic anxiety and disorders like MDD and PTSD by enhancing synaptic connectivity in the BLA [ 154].
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On the other hand, social situations may facilitate symptom interpretation and earlier diagnosis.
Decrease in posttraumatic stress was related to emotional stability and higher symptom levels at T1. Being referred to a mental health specialist did not facilitate symptom improvement.
We found that consulting mental health specialists did not facilitate symptom improvement, which was somewhat surprising as we expected that treatment would alter the course in favor of symptom reduction.
The estrogen withdrawal occurring during the menstrual cycle may favor reduced habituation of nociceptive cortex, which may facilitate pain symptoms and migraine in predisposed women.
In the same study, a short sleep duration seemed to facilitate the symptoms of central sensitization in adult primary headache [8].
Altered emotion processing manifest in alexithymia has been suggested to facilitate somatoform symptoms, dissociation and FNS [ 4, 6, 28, 62].
Any increased sensitization of the nociceptive receptors could affect the response of the afferent nerve fibers, causing central hyperexcitability of the neurons in the dorsal horn of the spinal cord affecting trigeminal nucleus and facilitating headache symptoms.
Moreover, according to the previous study results, a large-scale epidemiological study that included endoscopic examination could facilitate correlation between symptoms and endoscopic findings and clarify this relationship.
Being invited to participate in a trial about depression seems to facilitate acceptance of symptoms, may reduce stigma and allow older people to disclose their feelings, name the problem, and access care.
The use of such outcomes is particularly common for products developed to treat chronic, disabling conditions where the intention is not to cure but to ameliorate symptoms, facilitate functioning or, ultimately, to improve quality of life.
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CEO of Professional Science Editing for Scientists @ prosciediting.com