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For a codon J coding for an unobserved amino acid, the maximum-likelihood estimate (MLE) of F J, K tends to −∞. (Exceptions may exist when an unobserved amino acid may help facilitate substitutions between observed amino acids, such as pairs that cannot be connected by a single-base change).
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▪ Promote more efficient use of time and facilitate substitution of online consultation for in-person visits.
To facilitate substitution of individual arms, the EcoRI and HindIII sites present in the polylinker of pSYN-ALM were destroyed by site-directed mutagenesis with the QuikChange Site-Directed Mutagenesis kit (Stratagene) using the manufacturer's protocols.
In the long run, then, higher gasoline prices should change the look of neighborhoods and cities, increasing the feasibility of alternate transportation modes, and facilitating substitution between cars and other means of getting around.It's possible, maybe probable, that substitution away from driving might entirely counteract the rebound effect mentioned above.
This cassette contains a PGK-neo transcription unit to allow positive selection of G418 resistant transfectants, and a MC1-thymidine kinase (TK) minigene that enables negative selection using gancyclovir, thereby facilitating substitution of the entire cassette by recombination-mediated cassette exchange via flanking heterospecific LoxP and Lox511 sites (Figure 1).
The concept of "alternatives assessment" moves this concept forward by providing a process for identifying and comparing potential chemical and nonchemical alternatives to a chemical of concern to facilitate informed substitution [ 4, 5].
Measures to facilitate training included substitutions (in 5 of 17) and the inclusion of IPV training targets into "program contracts" (7 out of 17).
To better understand how S162A and Q266I substitutions facilitate the IFN induction of hSTING by DMXAA, we solved the cocrystal complex of DMXAA with hSTINGS162A/Q266I (aa 155 341) at 2.42Å resolution (X-ray statistics in Table S1).
In a B2B sense it facilitates the substitution of an outside supply chain for company-owned manufacturing.
Porous morphology was accompanied with partially facilitated Pt substitution reaction while hollow shape was exclusively achieved when the galvanic reaction was coupled with additional pre-treatment process which could eventually make the following displacement reaction more facile.
One of the best health interventions of the last Labour government was the setting up of the National Treatment Agency for Substance Misuse to facilitate access to substitution treatment for heroin addicts.
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