In time, it is anticipated that this comprehensive approach to data collection will allow early identification of individuals most susceptible to disease, as well as facilitating refinement of prevention and treatment programs.
These dual effects of the immune system on developing tumors facilitated refinement of the cancer immunosurveillance hypothesis into the 'cancer immunoediting' hypothesis proposed by Schreiber et al. In this project, we report novel findings relating to tumor-specific evasion of immune-mediated cell death by transforming growth factor (TGF)- β1- and hypoxia-dependent mechanisms.
Accordingly, the partnership has developed an integrated model of implementation, operational research, and impact evaluation to facilitate refinement and rigorous evaluation of the intervention.
Recent developments in SHELXL facilitate refinement against neutron diffraction data, the treatment of H atoms, the determination of absolute structure, the input of partial structure factors and the refinement of twinned and disordered structures.
Due to its comprehensive, interdisciplinary nature, instructive design, and flexible structure, however, the curriculum can benefit other health-care professional systems by serving as a model curriculum, and facilitating refinement and testing of other existing, but perhaps as yet unpublished models.
Giving participants the opportunity to discuss the rationale for presented ideas was thought to help build group cohesion, facilitate the refinement of disparate ideas [ 17], and assist in reaching consensus [ 16].
Inherent mechanisms for feedback and content delivery demonstrate the effectiveness of remote, collaborative ontology development and facilitate future refinement of the HAO.
The GMB session closed with a reflection on the insights prompted by the preceding analysis and the availability of data to facilitate quantitative refinement of the model.
We did not enrol previous users of the service because staff of the Evidence Centre usually facilitate the refinement of clinical questions during consultation sessions and it was postulated that some learning effect would be present.
The discovery of CRISPR (clustered regularly interspaced short palindromic repeats), a naturally occurring enzyme system that edits DNA in certain microorganisms, greatly facilitated the refinement of genome editing for de-extinction.
