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Visualising the penetration pathway of a lipophilic model dye into the hair follicle of fresh unfixed human skin would facilitate optimisation of drug formulations for local delivery to the pilosebaceous unit.
If more data become available linking exposure and efficacy of HuHMFG1, this model would facilitate optimisation of the dose level and dosing schedule.
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Inspection of the simulated results then facilitates optimisation of the trial design and proposed methods of analysis.
These data could provide important information on disease progression, as well as facilitating optimisation of treatment.
This paper presents an aggregation schema to facilitate the optimisation of urban energy systems at city scale.
Collectively, the data we present on structure-based design of eIF4E cap-binding inhibitors should facilitate the optimisation of such compounds as potential anticancer agents.
Understanding the relationship between microbial diversity and bioreactor performance could facilitate the optimisation of bioreactor design and enable the solution of bioreactor-related problems.
These methods allow access to greater synthetic diversification and have enabled the synthesis of compounds that have and will continue to facilitate further optimisation of the AF chemotype into a drug-like lead.
In this study, a series of kinetic models has been applied (logistic modified Gompertz, logistic logistic, and generalised logistic) which describes the experimental data, obtaining a set of parameters of biological significance which facilitate the optimisation of the use of these bacterial strains in the mass production of rotifers.
Elucidating the CAM-mediated cell-surface interactions that are essential for the in vitro maintenance of pluripotency will facilitate the optimisation of hPSC culture surfaces.
A detailed understanding of the effects of CAM-surface interactions on hPSC phenotype and behaviour in culture should facilitate the optimisation of defined culture conditions to support both hPSC self-renewal and somatic differentiation pathways.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com