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For instance, changes in the conformation stabilizes the oligomeric form of prokaryotic enhancer binding protein, NtrC1; binding of ATP analogues stabilize oligomeric form of the protein and facilitate its binding to Sigma 54 [27].
Results: The crystal structures reveal how BFRs mimic estradiol binding as well as the various interactions between the compounds and protein residues that facilitate its binding.
On the other hand, the amphipathic nature and the more rigid cyclic structure of cFΦR4 should facilitate its binding to neutral lipid membranes.
These binding features of X-2 could facilitate its binding to the embedded xylan chains and may explain the very stable X-2 staining in the present study.
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It is thought that an avian influenza virus will only be able to infect people efficiently if the hemagglutinin protein mutates in a way that facilitates its binding to human cell receptors.
At the molecular level, the interaction of Png1p and Rad23p leads to the opening of the conformation of Rad23p, which in turn facilitates its binding to the proteasome and/or ERAD substrates [16].
Our data also show that the sialic acids exposed on the erythrocyte membrane contribute for the interaction with fibrinogen, possibly by facilitating its binding to the erythrocyte membrane receptor.
Ubiquitination of Dvl facilitates its binding to the autophagic receptor p62 which allows LC3-mediated autophagic degradation of Dvl to downregulate Wnt signaling [ 84].
It has been suggested that increased expression of pha-4 during DR or TOR inhibition facilitates its binding to DR-specific genes, in an analogous manner to its expression and binding specificity during embryogenesis (Panowski et al., 2007).
During autophagy induction, LC3-I, a cytosolic form of LC3, is converted to LC3-II by lipidation, which facilitates its binding with the membranes of autophagosomes (Kabeya et al, 2000).
Importantly, however, GATA2 also functions as a global pioneer for GATA1 during erythropoiesis, facilitating its binding to a subset of GATA-regulatory elements, influenced by the underlying DNA sequence.
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