Sentence examples for facilitate gdp from inspiring English sources
GEF proteins have evolved to facilitate GDP dissociation and the subsequent GTP loading of Rab proteins.
Exchange of GDP with GTP is catalyzed by RabGEFs which facilitate GDP release and thus activate Rabs.
Whereas the Ragulator possesses guanine-nucleotide-exchange factor (GEF) activity towards RagA/B to facilitate GDP exchange for GTP, hydrolysis of bound GTP is influenced by another protein complex, GTPase-activating protein towards Rags (GATOR1), which has GAP activity towards RagA RagB [ 8].
This substitution was made because O2– is unable to facilitate the GDP dissociation from C118S Ras and wt Ras-SNO.
The KO2-mediated wt Ras GDP dissociation was abolished by treatment with SOD (Table 1), suggesting that O2 derived from KO2 is the active species to facilitate wt Ras GDP dissociation.
We propose that these residues may facilitate exchange of GDP for GTP by eEF1A.
The best explanations for these results are (i) O2– interferes with the catalytic action of Cdc25 on the wt Ras GDP dissociation, so that the kinetic characteristics of the Cdc25-mediated wt Ras GDP dissociation were fated; and (ii) O2– continuously facilitates wt Ras GDP dissociation in the presence of Cdc25 that exhibits the signatures of the O2 -mediated wt Ras GDP dissO2 -mediated
In this conformational state, the Rabex-5-Rabaptin-5 complex can facilitate the exchange of GDP- to GTP-bound Rab5.
The specific modifications of the catalytic interface in GMS proteins may facilitate complex formation with GDP-bound GKS proteins, thus prolonging their inactive state in the absence of infection.
Rh* facilitates exchange of GDP bound to Tα with cytosolic GTP, resulting in dissociation of the ternary complex into Tα-GTP, Tβγ, and Rh*.
For guanine nucleotide binding, cell lysates were incubated for 15 minutes at 30°C in the presence of 10 mM EDTA and 100 μM GTPγS (Roche, Rockford, IL, USA) or 1 mM GDP (Sigma) to facilitate nucleotide exchange as described in Knaus et al. [ 15].
