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The three-quarter-dose is mainly intended to facilitate gradual escalation from the mid- to full-dose.
Alternatively, using IMRT from the beginning of radiotherapy, using a belly board, and inserting a spacer between the recurrent tumor and OARs may further facilitate dose escalation without increasing the risk of radiation injury.
This should facilitate de-escalation from broad-spectrum to narrow-spectrum antibiotics, substantially improving patient management and supporting efforts to curtail inappropriate antibiotic use.
A faster and more accurate microbiological diagnosis should facilitate de-escalation from broad-spectrum to narrow-spectrum antibiotics, substantially improving patient management and supporting efforts to curtail inappropriate antibiotic use.
Its role continues to evolve in line with advances in radiation technology, which have facilitated dose escalation and reduced toxicity.
A reduction of the number of nodal stations to be irradiated would facilitate tumor dose escalation.
We explore the concept of spatiotemporal fractionation as an approach to facilitate further dose escalation in liver SBRT.
The present study was designed to test the hypothesis that a reduction in disease volume during radiotherapy detected by FDG PET/CT would facilitate radiation dose escalation, whilst remaining within normal tissue constraints.
Our findings suggest that FDG-PET/CT-guided IMRT can facilitate focal dose escalation to regions with SUV above 2.0 while providing normal tissue protection in patients with postoperative local recurrent rectal cancer.
Alternatively, IMRT/IGRT may facilitate EBRT dose-escalation of radiotherapy protocols and more aggressive combinations of radiotherapy with cytotoxic chemotherapy and/or novel systemic agents.
FDG-PET-guided IMRT can facilitate focal dose-escalation to regions with SUV above 2.0 for postoperative local recurrent rectal cancer.
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