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Indeed, an emerging theme in neuronal intracellular signaling is the hypothesis that both membrane-associated and intracellular signaling proteins are organized into discrete structural and functional microdomains that facilitate efficacious intracellular signaling [40].
Additionally, 3D in vitro cell culture models better represent in vivo tumor drug response, which would facilitate efficacious therapy development at the preclinical stage [ 29].
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Issues associated with cross-accreditation and transportability of qualifications are now recognised as key barriers in facilitating the efficacious movement of health care providers and meeting rapidly shifting international demands.
Biomarker validation could track mechanisms and lower trial costs and facilitate choice of efficacious doses before proceeding to longer term, more costly trials to evaluate conversion to AD.
To facilitate dissemination of efficacious, evidence-based community strategies to pediatricians and other child health advocates, we classified strategies by level of evidence and summarized the results in Figure 2.
The focus in resource-constrained settings has largely been on establishing functioning systems to facilitate implementation of efficacious PMTCT interventions, and great strides have been made in this regard, including in South Africa [ 24, 32].
Identifying methods to improve assay sensitivity in randomized clinical trials (RCTs) may facilitate the discovery of efficacious pain treatments.
This method may facilitate rapid discovery of efficacious direct drug conjugates by allowing informed selection of linkers and cargo based on endocytic trafficking.
This information can be used for documenting the health effects of exposures to lead which will facilitate identifying and monitoring efficacious treatments for lead-related maladies.
The development and clinical implementation of gene signatures that predict response to commonly used chemotherapeutic agents could facilitate selecting the most efficacious therapeutic regimen given the molecular characteristics of an individual's tumor.
These characterizations may facilitate the design of an efficacious vaccine for streptococcal mastitis in the dairy cow.
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