Integrin-mediated attachments can also promote cell spreading [41], but the cell may also require syndecan-1 as an additional signal to re-organize the actin cytoskeleton and facilitate cell spreading [42] [49].
At an intermediate surface density (2.7 × 109 molecules/mm), cell adhesion is more weakly promoted with cellular processes extended but not sufficiently strengthened to facilitate cell spreading.
To initiate cell spreading, a cell must prevent or disrupt skelemin binding to allow for the recruitment of other proteins to integrin clusters that facilitate cell spreading, such as talin and Src.
The biological 3D construct could maintain cell viability, thereby facilitating cell spreading and matrix formation.
Increasing Me-Gel concentration resulted in lower stiffness and higher viscosity, facilitated cell spreading, and better maintained HAVIC fibroblastic phenotype.
The mechanically strong PCL scaffold served as a skeleton, while the Gel/SG5 fibers facilitated cell spreading and mineralization of the scaffold.
The addition of Me-Gel in Me-HA facilitated cell spreading, proliferation and VIC migration from encapsulated spheroids and better maintained the VIC fibroblastic phenotype.
Aulic S, Masperone L, Narkiewicz J, et al. Alpha-synuclein amyloids hijack prion protein to gain cell entry, facilitate cell-to-cell spreading and block prion replication.
An adhesive macroporous hydrogel system, in which cell-affinitive domains and sufficient cytoskeleton reorganization space were simultaneously constructed, was proposed in this report to support cell adhesion and spreading, respectively, and facilitate cell differentiation and function establishment eventually.
As they are secreted serine proteases, their actions through the degradation of the extracellular matrix may facilitate tumour cell spread.
