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Actin regulators facilitate cell migration by controlling cell protrusion architecture and dynamics.
Later during transformation, higher Src activity, in addition to a reduction in EVL levels, would disassemble stress fibres to facilitate cell migration.
Later during transformation, higher Src activity, in addition to a reduction in EVL levels would disassemble stress fibres to facilitate cell migration (Fig. 9). Figure 9: Model by which stress fibre and cell stiffening sustain proliferation.
A matrix composed of shorter fibers may facilitate cell migration by effectively reducing the apparent viscosity of the tissue as cells may be less globally interconnected.
We report here that Sema3E from tumor cells can act on themselves through Plexin-D1 to induce EMT and concomitantly facilitate cell migration and malignant progression.
A large number of proteins common to plasma from tumor bearing cell lines and human ovarian cancer cells were found to be involved in cellular/tissue remodeling and cell-cell contact/communication that dictate alterations in ECM processes and facilitate cell migration, local tumor growth, and tumor metastasis.
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The ability for the scaffold to provide (i) an ideal environment for the cells to migrate, (ii) porosity that facilitates cell migration and crosstalk, and (iii) a biocompatible material are necessary to achieve proper healing in vivo.
The addition of channels facilitated cell migration and subsequent deposition of cartilage-specific matrix into more central regions of these explants.
In vivo, the scaffolds facilitated cell migration that resulted in rapid cutaneous-tissue regeneration and tissue-structure formation within five days.
For instance, MMP-2 can cleave the adhesive contacts and cellular networks that cells use to adhere to their basement membrane, facilitating cell migration [14], [34], [35].
Heparanase is thought to act both as a hydrolytic enzyme, facilitating cell migration and release of ECM-resident bioactive factors, and as a signalling molecule, independent of its enzymatic activity [19], [50], [51].
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