Sentence examples for facilitate breakdown from inspiring English sources

Heparanase can facilitate breakdown of the extracellular matrix which aids tumor cell migration and releases factors that promote tumor growth, angiogenesis and metastasis [1].

The functional repertoire of the intestinal cell differs: the apical side is equipped with the brush border containing a large number of enzyme and transporter complexes such as lactase, sucrase and aminopeptidase that facilitate breakdown and absorption of nutrients from the gut lumen into the blood circulation [25].

MMP7 and MMP12 levels are elevated in lung cancer, which may facilitate breakdown of the extracellular matrix and tumor spread.

However, complex tumour-stromal interactions may result in changes to the stroma that facilitate breakdown of the basement membrane and allows tumour cells to invade the surrounding ECM.

In these situations, human impacts on animal habitats facilitate breakdowns in spatial, temporal, and behavioral isolating mechanisms of previously distinct species [8], [9].

Autophagolysosomes and phagolysosomes are terms used to describe the compartments within these two pathways that have undergone lysosome fusion which facilitates breakdown of internal components.

Facilitated breakdown of ATP in the RVLM not only prevented an increase in plasma level of noradrenaline, but also attenuated the progression of LV remodelling in a rat model of heart failure secondary to MI.

CA IX has been shown to play an important role in pH regulation and its expression has been suggested, in response to hypoxia, to reduce the pericellular pH and facilitating breakdown of the extracellular matrix [ 1].

To test the efficacy of TMPAP expression in facilitating breakdown of extracellular ATP, the spread of Ca2+ excitation was assessed by measuring the distance from the stimulated cell to the further-most responding cells in the area of stimulation (Fig.  1c) and the profile of Ca2+ responses in individual astrocytes was determined (Fig.  1d).

Facilitated breakdown of extracellular ATP in the rostral ventrolateral medulla oblongata by virally-driven overexpression of a potent ectonucleotidase transmembrane prostatic acid phosphatase results in a significant reduction in the arterial blood pressure in the spontaneously hypertensive rats (but not in normotensive animals).

For example, cellulosomes are large complexes consisting of multiple cellulolytic enzymes that rely on the concerted actions of different enzymes built onto a common protein scaffold to facilitate the breakdown of the polymeric substrate, cellulose.