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Zhou, J. et al. Selection, characterization and application of new RNA HIV gp 120 aptamers for facile delivery of Dicer substrate siRNAs into HIV infected cells.
For instance, the small size (below 1 micron) enables facile delivery throughout the body and into cells by crossing the plasma membrane [44].
We are unaware of any system that permits the facile delivery of antibody mimics ranging in structural diversity as shown here.
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Peptides are considered, enabling chemical synthesis and more facile intracellular delivery, given their smaller size.
The incorporated procedures of facile reagent delivery, fluid handling and amperometric detection using microfluidics allowed replicating the workflow of benchtop ELISA technique.
To allow continuous and facile peptide delivery throughout the 4-day incubation period, mice were implanted with osmotic pumps the day prior to cell transfer.
The HA-NP is composed of a highly anionic polymer that cannot form polyelectrolyte complexes with anionic RNA for facile cellular delivery.
Fourth, InCell SMART-i is simpler and easier to perform relative to the artificially synthesized nanoparticles, which face practical issues such as facile intracellular delivery,[ 3c, 4] because of the use of biologically self-assembled ferritin complexes inside cells.
Because of the failure – after more than a decade of intensive inquest – to find robust mammalian homologs of C. elegans RNAi accessory mechanisms or to develop facile oral delivery methods for RNAi [ 82], a report published online in late 2011 took the scientific community by surprise.
Using a simple cell culture well format, the NES delivers into >100,000 cells within 20 s with >95% cell viability, enabling facile, dosage-controlled intracellular delivery for a wide variety of biological applications.
A defining therapeutic feature of a biodegradable polymer used in modern drug delivery is facile degradation into oligomers or monomers with concomitant kinetically controlled-drug-release profiles.
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