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When multiple steps in a pathway are upregulated, previously unsuspected facets of the pathway might be revealed, such as the newly uncovered bifunctional substrate preference of the key regulatory enzyme in tocopherol (vitamin E) biosynthesis, homogentisate phytyltransferase.
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Collectively, these data indicate that a functional PfATG8 conjugating system is present at the proteomic level and highlight the multiple facets of this pathway in the parasite's infectious cycle progression.
APG1 kinases in yeast and A. thaliana are a target for the negative regulation of autophagy by TOR [ 98, 99], highlighting another conserved facet of the TOR pathway.
Further discussion of this facet of the biosynthetic pathway is beyond the scope of this review, except for the few instances that have been presented with a particular metabolic step, such as the compartmentation of GalCer biosynthesis in the lumen of the ER.
This review aims to give an update on the various facets of FOH synthesis pathway including the features of involved genes and enzymes, and recent progresses on FOH production.
Several excellent reviews provide insight into the many facets of drugging the Wnt pathway in cancer [154]– [154].
Systems biology refers to the integration and analysis of complex datasets derived from multiple facets of the body's signaling and response pathways (that is, genomics, transcriptomics, proteomics, and metabolomics).
This reveals another facet of the coupling between pathways through shared components.
Many excellent reviews have described the reaction pathways of AGE formation, their structure, relationship to aging and disease, and other facets of the field [ 3].
In summary, LXRs may modulate critical facets of cellular death pathways in the ischemic and infarcted myocardium.
Others have illuminated facets of the crisis in more depth.
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