Sliding clamps participate in numerous facets of DNA metabolism that include DNA replication, DNA repair and chromatin modifications such as assembly of higher-order chromatin complexes [1].
It is believed that RecQ helicases have multiple roles in three facets of DNA metabolism (repair, replication and recombination), S-phase checkpoint, and telomere maintenance; consequently, they are considered caretakers of the genome [1], [2].
Other articles in this issue present data that improve our understanding of both laboratory facets of DNA fingerprinting (i.e., IS 6110 fingerprinting) and basic science of M. tuberculosis.
Induction of cell senescence is one of the facets of DNA damage response, and it provides the barrier preventing tumor development (9, 11– 16) as well as impeding formation of induced-pluripotent stem cells (iPSCs) and potential initiators of neoplastic transformation (55).
An important way in which various organisms coordinate facets of the DNA damage response is the post-translational modification of proteins.
While genotoxic agents are strongly linked to tumorigenesis, the cytotoxic effect of DNA damage is also a critical facet of cancer therapy.
To investigate the genetic basis of DNA methylation, we performed genome-wide association studies (GWAS) using different facets of average methylation as the phenotype.
New knowledge that TGFβ regulates the DNA damage response, which underlies cancer therapy, reveals another facet of TGFβ biology that impedes cancer control.
Variability is another facet of the climate.
Is this a facet of his personality?
