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'face unique challenges' is correct and usable in written English.
You can use it when referring to a situation that is difficult to deal with due to its specific or unusual nature. For example: "The project team has to face unique challenges due to its complexity."
Exact(60)
Girls face unique challenges... Some of our most pressing social problems are uniquely or more acutely experienced by girls.
Family businesses face unique challenges, as well as opportunities.
Heavy off-road vehicle suspension systems face unique challenges.
But when it comes to dressing young and hip, some Mormons said they face unique challenges.
Companies face unique challenges in trying to build businesses at the bottom of the pyramid.
Impersonators are not immune to these economic forces and face unique challenges.
Rural populations face unique challenges to physical activity that are largely driven by environmental conditions.
Patients diagnosed with laryngeal cancer and their families face unique challenges.
Businesses that service multicultural customer segments face unique challenges in developing the appropriate service strategy.
They face unique challenges in addressing the need for sufficient data rate without using a power supply.
On the other hand, nanocarriers face unique challenges in controlling drug release kinetics, due to the large surface area per volume ratio and the short diffusion distance.
More suggestions(14)
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com