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A prior literature review found limited evidence to recommend any particular face to face intervention other than to incorporate communication about vaccination effectiveness during an encounter.
Interestingly, the size effect of TR on global cognition was similar to that obtained from our study, MMSE score increase of 2 3 points and comparable to that of face to face intervention.
As it was not possible for the participants to always be blinded to whether they were seeing a doctor, nurse, or other health professional, this limitation must be accepted for any face to face intervention.
M-CT-arm: This M-CT treatment builds on a previously evaluated face to face intervention, i.e. Preventive Cognitive Therapy (PCT) [ 14] and has been developed in collaboration Bockting & van Valen [ 15] with the Trimbos Institute.
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Face to face interventions are the most common strategies.
Face to face interventions have limited scalability for population use, and it is highly desirable to use new technologies and methods for intervention design to develop methods that are both effective and scalable.
We found no significant evidence that specific modes of intervention delivery were more effective, although face to face interventions displayed a tendency to be more effective than remotely delivered ones (such as internet or telephone).
Assuming a reduction of 30% in the proportion of risky drinkers in the face-to-face intervention group and allowing for an overall attrition of 10% of patients in the trial, it is calculated that 500 patients will be required in each group to give the trial 90% power (1-β) to reject the null hypothesis that facilitated access is inferior to face-to face intervention.
Materials were sent by mail to those who did not attend the face-to-face intervention.
The face-to-face intervention is designed to be interactive and actively elicits the participant's participation.
An individualized written physical activity plan will be developed during the face-to-face intervention.
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